鼠Prion启动子(包括Prion蛋白基因上游1140bp,完整exon1,内含子1以及exon2的前52bp),驱动表达全长的人类ATAXIN-3(ATAXIN-3c亚型),该亚型含有148个CAG重复。为了将ATAXIN-3送入细胞质,其核输出信号(NES)被连接到了ATAXIN-3上。建立了五条转基因品系:NES.17,NES.24,NES.34,NES.40和NES.42。(来源:J:122993)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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