这个编码序列(4到13号外显子)被替换了loxP位点,包含一个由cDNA编码的Pax6的替代剪接异构体,它在PD域内插入了14个氨基酸,改变了DNA结合特异性(5a)。这个等位基因还带有FRT引导的诺卡因抗性/终止子、loxP位点以及Pax2的cDNA。这个等位体表达的是Pax6的5a异构体(Pax6_i5a)。(来源:J:198381)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
20
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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