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中文
在exon 2的两侧插入了LoxP位点，然后在intron 2内插入了由FRT标记的neo cassette。随后，通过将这些经过正确靶向的鼠与表达flp重组酶的鼠杂交，移除了选择性 cassette。最后，这些鼠再与表达Cre的鼠杂交，以去除包含RING域的exon 2。这产生了长度较小、框内序列的转录本，表明RING域已缺失。(来源：J:196137)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
