Drc3^m6Bei

The molecular lesion in Lrrc48 (NM_029044) is located at Chr11:60363569 bp (exon4: c.T266C: p.L89P). This is a missense mutation that substitutes proline for leucine. qRT-RCR analysis using primers for exon 89 confirmed a reduction of gene expression in the mutant to 34% of wild-type levels (P greater than 0.001). (J:199782, J:240195)