一段36个碱基对的延伸,使得初始的多聚亮氨酸序列从14个 alanines 扩展到了26个。通过 Morula 注入,产生了杂合体,其中突变细胞贡献高达95%。此外,还插入了一个FRT引导的neo选择座。尽管进行了广泛的育种,但这些杂合体中没有一个表现出突变基因的遗传给后代。(来源:J:195300)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部