这种突变是通过Ptf1a/Ptf1aostm1Kymm基因的重组实现的,交换了带有CAG启动子驱动Ptf1aos首尾两个外显子普遍表达的neomycin抗性基因座,后面跟着FRT切割位点、puromycin抗性基因座和lox2272位点。这个突变是在含有Etn2Sd的ES细胞中创建的(来源:J:195133)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
4
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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