这种突变是通过Ptf1a/Ptf1aostm1Kymm基因的重组实现的,交换了带有CAG启动子驱动Ptf1aos首尾两个外显子普遍表达的neomycin抗性基因座,后面跟着FRT切割位点、puromycin抗性基因座和lox2272位点。这个突变是在含有Etn2Sd的ES细胞中创建的(来源:J:195133)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count