通过同源重组,将一个带有 floxed PGK/Tn5 置换Neo抗性基因座的病毒长末端重复(neo cassette)和Akv1-99小鼠白血病病毒的长末端重复(LTR)插入到promoter区域。病毒的LTR以顺式方向插入到了前病毒整合位点3。 Western blot结果显示胸腺和脾脏中蛋白表达有所增加。(来源:J:199340)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
21
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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