一段1.9kb的基因组片段,包含714bp的下游调节区,被替换为一个由PGKneo选择标记驱动的片段,这个标记带有loxP序列的对。随后,通过暂时的Cre表达,去除了这个neo选择标记。Northern blot结果显示了恢复的转录表达水平。(来源:J:76260)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
插入,基因内删除
--
1
4
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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