在Eomes基因的1号外显子起始翻译位点,通过同源重组插入了cre/ERT2-polyA cassette和一个loxP引导的诺姆选择 cassette。这导致1号外显子编码区域大约500bp的缺失,产生了一个无义突变基因(null allele)。最终敲入基因中去除了诺姆选择 cassette。原位杂交结果显示,cre/ERT2在胚胎中的表达模式再现了内源Eomes的时空表达模式。(来源:198846)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv-Gpi1c
Targeted
插入,基因内删除
--
1
1
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部