Kif7^b2b2254Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide position 557 in exon 3 of the cDNA (c.557T>A, NM_010626). This changes the valine residue to glutamic acid at position 186 of the encoded protein (p.V186E). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Kif7b2b2254Clo, and may be present in stocks carrying this mutation.