这个构建包含了靶向位点的序列,包括一个带有Neomycin抗性/STOP cassette的敲除元件、人类EIF1AX启动子、Caldocellum saccharolyticum的β-葡萄糖苷酶(bglA)基因以及一个polyadenylation序列。除了小肠,需要通过Cre介导的重组来实现报告基因的表达,因为那里会检测到背景活性。(来源:J:196052)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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