Alb^em12Mvw

Exon 4 was targeted by introduction of TALEN mRNA into fertilized B6.Cg-Fcgrttm1Dcr Tg(FCGRT)32Dcr/DcrJ oocytes and the resulting founder screened and found to have a 2 base pair deletion beginning at Chromosome 5 base 90,464,113 (GRCm38.p2) which is predicted to result in a frame shift then a premature stop codon 5 amino acids downstream of the encoded frame shift. By ELISA, heterozgyotes have a decrease in serum albumin of approximately 30 percent and homozygotes have no detectable serum albumin. (J:220803)