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中文
将BAC(RP23-2B8)中Sox2基因的编码序列替换成tamoxifen诱导型Cre/雌激素受体融合蛋白(cre/Esr1*; CreERTM)的编码序列。这个构建被注入了FVB卵母细胞的初级卵母细胞中。获得了3个转基因阳性个体(个体20、34和36)。这些个体与报告型小鼠杂交，E9.5时给予tamoxifen处理，然后在E10.5时分析胚胎的重组活性。后代中，线20的后代显示出最强烈的lacZ表达。这个特定的后代被进一步研究。(来源：J:195589)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
