小鼠Thy1启动子驱动表达包含瑞典(K670N/M671L)和伦敦(V717I)突变的hAPP751 cDNA。免疫组织化学显示人APP在新皮质和海马体有高表达,基底ganglia和小脑的表达适度。建立了三线,16、11和41。41线是表达最高的。(引用:J:162842)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count