小鼠Thy1启动子驱动表达包含瑞典(K670N/M671L)和伦敦(V717I)突变的hAPP751 cDNA。免疫组织化学显示人APP在新皮质和海马体有高表达,基底ganglia和小脑的表达适度。建立了三线,16、11和41。41线是表达最高的。(引用:J:162842)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x DBA/2)F1
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1
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36

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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