设计了一种靶向载体,它在exon 2的上游插入了loxP位点,并在exon 2下游包含一个由frt和loxP序列包裹的诺卡因抗性(neo)基因座。通过Flp介导的重组,neo基因座被剔除,exon 2区域被标记为可删除的。(来源:J:196943)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6J x 129S4/SvJae)F1
Targeted
插入
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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