Lrp2^b2b1625.2Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1625Clo. The molecular lesion is an A to G substitution at nucleotide -3 before coding nucleotide 8456 (c.8456-3A>G, NM_001081088) in intron 44. This changes splice acceptor site AAG to TAG (which may have a different efficiency). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Lrp2b2b1625.2Clo, and may be present in stocks carrying this mutation.