Snx17^b2b1625.1Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1625Clo. The molecular lesion is an A to G substituation at coding nucleotide 431 in exon 5 of the cDNA (c.431A>G, NM_153680). This changes the glutamic acid residue to glycine at position 144 of the encoded protein (p.E144G). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Snx17b2b1625.1Clo, and may be present in stocks carrying this mutation.