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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Zbtb7b
tm5.1Itan
Alias:
Thpok
gfp;deltaTE
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基础信息
表型特征
文献报道
使用了先前被定向插入GFP报告基因的ES细胞。靶向载体去除了尾部调控元件的胸腺增强子(TE),但保留了沉默序列。在沉默元件附近插入了含荧光素基质诺卡因的选择标记。最终,通过暂时的Cre表达,删除了耐药基因座。(来源:J:193321)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
5486336
(129 x C57BL/6)F1
Targeted
基因内删除
--
1
--
2
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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