Tg(Scx-cre)HShuk

A construct was generated with the cre recombinase sequence under control of approximately 11 kb of the Scx regulatory region (~4 kb of upstream sequence and ~5 kb of downstream sequence, retrieved from a bacterial artificial chromosome RP23-415D19). This construct was used to produce transgenic animals. Two lines were established with low transgene copy number (L) and high copy number (H). When lines were bred to reporter mice, cre activity was detected overlapping various Scx-positive expression domains including chondrogenic, tendonogenic and ligamentogenic regions, as well as in the lung, kidney and testes. (J:195053)