在exon 2插入了DsRed报告基因和含floxed neomycin抗性元件的 cassette,导致了框移和早停密码子。随后通过cre重组酶去除了选择 cassette, Western blot结果显示了基因表达的丢失。(来源:J:192526)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count