通过同源重组技术,将cre/ERT2-IRES-EGFP-polyA-Frt-neo-Frt的 cassette插入到了Dclk1基因的第二个外显子起始密码子(ATG)之后的区域。在建立了生殖细胞遗传后,这个neo cassette在实验小鼠中通过与表达Flp的突变体杂交的方式在体内被剔除。(来源:J:193873)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入
--
1
--
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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