在小鼠胚胎干细胞中,通过同源重组,包含cre/ERT2序列和Otx2 3' UTR(带有polyadenylation信号及floxed neo标记)的磁带取代了Otx2的整个编码序列。随后,这些带有转基因的动物后代与CMV剔除小鼠杂交,以去除neo标记(来源:J:194049)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
10
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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