在exon 1下游插入了loxP位点。在exon 17下游,插入了带有3' loxP的FLAG标签和一个由FRT引导的neo cassette。通过Flp介导的重组移除了neo cassette,使得exons 2到17都被去除了loxP标记。 Western blot分析证实了大脑中没有蛋白表达。(来源:J:192445)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
2
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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