Tg(Ckm-Chrnd*S268F)1Cgz

A transgene was generated encoding an adult murine cholinergic receptor, nicotinic, delta polypeptide (Chrnd*S268F) under control of a murine creatine kinase, muscle (Ckm) promoter. A point mutation was introduced resulting in the deltaS268F mutation present in a patient with slow-channel congenital myasthenic syndrome (SCCMS). The 3' untranslated end of the deltaS268F cDNA was removed and replaced with the 3' UTR of the neomycin resistance gene (neo) and an intron from the SV40 small t intron. Line 1 was generated. (J:111294)