在基因的第3外显子下游插入了一个带有neo选择标记的敲除 cassette,然后在上游位置插入了第三个loxP位点。通过Cre酶的剪切,这些被精确靶向的鼠模型中,选择 cassette 和第3外显子随后被移除。(来源:J:191182)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
4
21

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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