一个带有敲除neo cassette的点突变构建产生了1个碱基的缺失,导致了 frameshift和一个在保守的10到15个氨基酸的C端序列下游的早停密码子。 Western blot结果显示,杂合子小鼠中,一个截短蛋白的表达确实减少了。(来源:J:192154)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Single point
--
1
4
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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