Exon 3被替换成一个带有floxed neo cassette的修饰过的Exon 3,其中A到C和T到A的突变导致了第2880位氨基酸由 alanine 改为 aspartic acid(替换为D2880A),第2885位由lysine变为asparagine(替换为N2885K)。这些变异产生了无活性的激酶。随后,Cre介导的重组移除了neo cassette。(来源:J:191288)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Nucleotide substitutions
--
1
26
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部