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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Rr21
tm1.1Jta
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基础信息
表型特征
文献报道
在染色体15的61449842-61451581(NCBI37/mm9)位置,一个1740bp的区域,距离Myc的转录起始点335kb上游,被LoxP和FRT序列所环绕。这个区域上方插入了一个由Neomycin抗性基因座驱动的,由Cre介导的重组会移除1740bp的区域和Neo cassette,剩下位于chr15:61490136(GRCm39)的单个LoxP位点。在P1期,纯合小鼠的结肠中Myc mRNA表达降低,但十二指肠中没有显著变化。ChIP分析显示,TCF7L2在这个区域的结合丢失了(J:191217)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
5463413
C57BL/6
Targeted
Insertion, Intergenic deletion
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2
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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