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中文
一段全长的人类TAR DNA结合蛋白(TARDBP或TDP-43)的cDNA序列被修改，其N端添加了myc标签，形成了huTDP-43-WT序列。这个huTDP-43-WT序列被插入到小鼠Prnp基因的第2外显子和第3外显子之间。构建的Prnp-TDP-43-WT转基因载体两侧带有loxP位点。产生了三条转基因小鼠品系，即65、93和96。其中，96代小鼠在脊髓中的TDP-43总表达量大约比非转基因小鼠内源性TDP-43高出1.5倍。（来源：J:191785）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
