通过Cre介导的重组,去除了带有loxP标记的第4个外显子,导致第5个外显子产生了一个早发性终止密码,由于移位引起框架错乱。 Western blot结果显示, sciatic神经中没有检测到蛋白表达。(来源:190437)
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The loxP flanked exon 4 was removed via cre-mediated recombination, generating a premature stop codon in exon 5 because of a frame shift. Western blot analysis confirmed lack of protein expression in sciatic nerve. (J:190437)