在exon 1上游插入了一个loxP位点,同时在intron 2内插入了FRT/loxP引导的诺卡因载体。通过与表达flp重组酶的转基因小鼠杂交,目标基因被精确地剔除了诺卡因选择性元件,保留了exons 1和2,这两端都带有loxP标记。随后,表达flp的转基因小鼠被繁殖掉。(来源:J:190168)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入
--
1
--
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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