在第七外显子上游插入了一个loxP位点。接着在第八外显子下游插入了一个FRT-介导的neo cassette,带有3'的loxP位点。通过Flp酶介导的重组,neo cassette被去除,使得第七和第八外显子被标记为可翻转。(参考文献: J:189838, J:190675)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
3
22

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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