从12到36号外显子被替换为一个包含人类cDNA、连接序列、雌激素受体(ERT或ERtm)突变的雌激素结合域、polyadenylation序列和floxed neo cassette的构建。这种预测的融合蛋白功能依赖于他莫昔芬治疗。(来源:J:189329)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因内删除
--
1
15
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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