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中文
FVB小鼠的129P2-Trp53背景中，Col1A1基因的3' UTR区域通过一个"Flp-in"质粒，携带有Frt-lox66-Cag-lox71-Luc2反转录增强子转基因，命名为inv-Cag-Luc2，与表达Flpe的质粒一起转染，以促进重组进入Col1a1基因座的3' UTR。这个转基因包含了驱动Hygromycin抗性基因表达的constitutive CAGGs启动子，该基因位于目标的Col1a1基因位点。当Cre重组酶表达时，由于周边的loxP突变位点（lox66和lox71）导致启动子发生反转，使其位于萤火虫Luc2基因的前端。参考文献：J:188992, J:210103
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
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