设计了一个靶向载体,用于替换Tcf21(也称capsulin或epicardin)转录因子21的第1外显子,通过插入mercremer蛋白,后面跟着Frt标记的neo cassette。载体两侧带有经过突变的雌激素受体(mer)配体结合域的Cre重组酶cDNA序列。通过Flp介导的重组会删除neo cassette。来源:(J:188837)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
--
30

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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