设计了一个靶向载体,用于替换Tcf21(也称capsulin或epicardin)转录因子21的第1外显子,通过插入mercremer蛋白,后面跟着Frt标记的neo cassette。载体两侧带有经过突变的雌激素受体(mer)配体结合域的Cre重组酶cDNA序列。通过Flp介导的重组会删除neo cassette。来源:(J:188837)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count