编码Pcdhga1、Pcdhga2和Pcdhga3的基因组序列被替换了lox2272位点介导的Hygro cassette,随后通过Cre酶的定向重组移除了Hygro cassette。通过删除这三个α亚基的外显子,这个突变体是三个A型isoform(即TAKO)的敲除型。(来源:J:188341)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count