在exon 2上游插入了loxP位点,通过同源重组在exon 3下游引入了FRT标记的neo cassette和另一个loxP位点。随后,Flp介导的重组去除了neo cassette。(来源:J:187107, J:188398)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count