一个新合成的cassette取代了大部分编码Jak同源域(JH)的外显子,包括JH7(部分)、JH6/5和JH4(部分)。 Western blot分析证实了骨髓巨噬细胞中蛋白表达的缺失。(来源:J:65408)
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A neo cassette replaced most of the exons encoding the Jak homology (JH) domains JH7 (partly), JH6/5 and JH4 (partly). Western blot analysis confirmed the absence of protein expression in bone marrow macrophage. (J:65408)