在PKHD1tm2Cjwa小鼠和Tg(Gdf9-cre)5092Coo小鼠杂交后,通过去除LSL(loxP-STOP-loxP) cassette,使得 intron 2中仅保留一个loxP位点。去除LSL后,该基因被重新激活,表达的蛋白质在N端带有两个SV5-Pk的标签。Northern blot结果显示,检测到了与野生型等同长度的13kb、9kb、7.7kb和7.5kb的产物。(来源:J:187735)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
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--
1
13
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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Year
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