Pkd1^b2b1585Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide 11084 in exon 38 of the cDNA (c.11084T>A, NM_013630). This changes the isoleucine residue to asparagine at position 3695 of the encoded protein (p.I3695N). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Pkd1b2b1585Clo, and may be present in stocks carrying this mutation.