在exon 3a插入了一个终止密码子,阻止了A转录本的产生。在修改后的exon 3a上游插入了一个floxed neo cassette。从4到6号外显子以及7的部分区域被删除,从而阻止了C剪接变体的表达。随后,通过Cre介导的重组移除了neo cassette。(来源:J:169366)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
1
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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