设计了一种靶向载体,其目的是在exon 1的起始密码子上游插入一个loxP位点。载体中包含了一个frt标签的诺卡因抗性基因(neo)区和第二个loxP位点,这些都位于exon 1之后。杂合子小鼠与Flp转基因小鼠杂交,以删除neo cassette(来源:J:187145)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
--
1
2
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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