α1和2号外显子被替换成一个带有floxed neo cassette的元件。通过Cre介导的重组,neo cassette被去除了。 Western blot结果显示肝脏、肾脏、脂肪储存、血清、心脏、肺、胃、小肠、脾脏、大脑和睾丸中均无蛋白表达(来源:J:118213)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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