α1和2号外显子被替换成一个带有floxed neo cassette的元件。通过Cre介导的重组,neo cassette被去除了。 Western blot结果显示肝脏、肾脏、脂肪储存、血清、心脏、肺、胃、小肠、脾脏、大脑和睾丸中均无蛋白表达(来源:J:118213)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count