将来自人类MHC II类基因HLA-DRA和HLA-DRB1*0405的转录产物,它们共同构成HLA-DR4,插入到小鼠MHC II类Ea基因的启动子区域(-2172至+12)之后。每个转录本的编码序列被插入到约1200bp的兔β-珠蛋白基因片段中,该片段提供了一个内含子、3'非翻译区(3'UTR)和polyadenylation信号(来源:J:182727, J:186300)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(NOD/Shi x NOD.Cg-Prkdcscid Il2rgtm1Sug/Jic)F1
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插入
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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