锌指内切酶介导的同源重组在野生型等位基因中插入了三个沉默突变(一个在第18个密码子的第三位,两个位于内切酶结合位点上游,其中一个还消除了Rab38cht和正常野生型等位基因都存在的ApaLI限制性酶切位点)。(来源:J:185512)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(FVB/NCrl x C57BL/6J-Rab38cht)F1
Endonuclease-mediated
核苷酸替换
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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