锌指内切酶介导的同源重组引入了核苷酸替换(GGT替换为GTA),导致第19位氨基酸由甘氨酸变为缬氨酸(G19V)。这种突变复制了在Rab38cht中观察到的氨基酸替换(来源:J:185512)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(FVB/NCrl x C57BL/6NCrl)F1
Endonuclease-mediated
核苷酸替换
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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