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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Ace
tm9Keb
Alias:
ACE 9
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基础信息
表型特征
文献报道
在内源性体细胞启动子和exon 1之间插入了新霉素抗性基因座、肾特异的Cadherin启动子以及人类β-珠蛋白的最小启动子。这种插入阻止了内源性体细胞启动子的功能,导致只在肾脏中表达。(来源:J:185888)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
5430660
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
4
1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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