在exon 5上游插入了loxP位点,下游则插入了neo cassette和另一个loxP位点。通过Cre介导的重组,exon 5被删除,neo cassette也随之去除。 Western blot结果显示,来自纯合小鼠骨髓衍生的巨噬细胞中,基因表达已确认缺失。(来源:J:160545)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
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49

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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