在exon 6的上游插入了loxP位点,通过同源重组,exon 9后面则整合了loxP位点和FRT标记的mcl-neo cassette。通过Flp介导的重组,去除了neo cassette,使得exons 6到9区域被标记为可删除的。(来源:J:185208)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count