在Exon 7位置插入了带有IRES-lacZ元件和一个floxed pgk-neo cassette,通过同源重组实现。随后,通过Cre介导的重组移除了neo cassette。在P28时,可以检测到内耳中 cristae ampullaris 的毛细胞有β半乳糖苷酶活性,而在saccular和utricular maculae的毛细胞中则非常微弱。(引用自J:184419)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
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1
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16

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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