在Exon 7位置插入了带有IRES-lacZ元件和一个floxed pgk-neo cassette,通过同源重组实现。随后,通过Cre介导的重组移除了neo cassette。在P28时,可以检测到内耳中 cristae ampullaris 的毛细胞有β半乳糖苷酶活性,而在saccular和utricular maculae的毛细胞中则非常微弱。(引用自J:184419)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count